ZYNRELEF vs Continuous Catheter for Pain Management Following Shoulder Arthroplasty

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT07280195
Phase
PHASE4
Status
Enrolling By Invitation

Conditions

  • Pain Management
  • Total Shoulder Arthroplasty

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Zynrelef — DRUG
    ZYNRELEF
  • Bupivacaine — DRUG
    Interscalene block with continuous catheter pump

Study Details

The purpose of this study is to determine if local intra-operative application of ZYNRELEF (topical medication) during shoulder replacement surgery improves pain control (as defined by opioid consumption after surgery) compared to the use of an interscalene block with catheter. This is a randomized clinical trial without blinding. Subjects will complete patient reported outcomes before and after surgery. Subjects will track their narcotic use, pain scores and pain satisfaction after surgery.

Key Dates

Start date
Feb 14, 2026
Status verified
Feb 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
86 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: ZYNRELEF
  • Active Comparator: Interscalene block with continuous catheter pump

Primary Outcome Measure

Narcotic consumption [ Time Frame: From surgery to two-weeks following surgery ]

Locations (1)

FacilityCityStateZIPSite coordinators
Washington UniversitySt LouisMissouri63110-

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By research site
Washington University· St Louis, MO

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