Efficacy of Methylprednisolone for Pain Control After ACL Repair

Part of paid clinical trials in St Louis, Missouri.

Sponsor
St. Louis University
Study ID
NCT07158476
Phase
PHASE4
Status
Recruiting
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Conditions

  • ACL Surgery
  • Pain Management

Eligibility Criteria

Sex
ALL
Age
13 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • Meloxicam 15 mg — DRUG
    PO once/day for 1 week
  • Medrol 4 MG Oral Tablet Includes Medrol Dosepak — DRUG
    PO 6 day taper
  • Gabapentin 300 mg — DRUG
    PO every 8 hours for 1 week
  • Hydrocodone 5Mg/Acetaminophen 325Mg Tab — DRUG
    PO 1-2 tabs every 4 hours as needed (total of 28 pills)
  • Ketorolac 10 Mg Oral Tablet — DRUG
    PO every 6 hours for 5 days

Study Details

Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repair surgery to determine if this results in decreased postoperative pain and opioid use without increasing complications.

Key Dates

Start date
Oct 21, 2025
Status verified
Oct 2025
Primary completion
Sep 30, 2030
Completion
Sep 30, 2031

Study Design

Enrollment
90 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Active Comparator: Medrol group
    Patients will receive Medrol dose pack, Meloxicam, Hydrocodone/Acetaminophen, and Gabapentin as pain regimen upon discharge from surgery.
  • Active Comparator: No Medrol group
    Patients will receive Ketorolac, Hydrocodone/Acetaminophen, and Gabapentin as pain regimen upon discharge from surgery.

Primary Outcome Measure

Numerical Rating Scale (NRS) pain scores [ Time Frame: Post-op days 0-14, 2 weeks, 6 weeks, and 12 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Saint Louis UniversitySt LouisMissouri63110-

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Saint Louis University· St Louis, MO

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