Propranolol for Misophonia

Part of paid clinical trials in Littleton, Colorado.

Sponsor
Bloom Mental Health, LLC
Study ID
NCT07271485
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Misophonia
  • Misophonia Treatment
  • Propanolol

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • propranolol — DRUG
    A one-time dose of 20 mg propranolol
  • Placebo — DRUG
    A dose of placebo taken orally

Study Details

The primary goal of this study is to investigate whether a one-time dose of 20 mg oral propranolol can temporarily reduce the adverse emotional and physical symptoms triggered by misophonia. The secondary goals of this study are: 1. Determine potential predictors of response to propranolol treatment, including demographic factors, baseline symptom severity, psychometric instrument item responses, and physiological characteristics. 2. Evaluate the safety and tolerability of propranolol in individuals with misophonia.

Key Dates

Start date
Dec 19, 2025
Status verified
Nov 2025
Primary completion
Dec 19, 2026
Completion
Dec 19, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Propranolol Pill
    10 participants will take one-time dose of 20 mg propranolol pill
  • Placebo Comparator: Placebo Pill
    10 participants will take be given a matching one-time dose of placebo

Primary Outcome Measure

Heart Rate [ Time Frame: Heart rate is continuously monitored via pulse oximetry during each video presentation. The continuous measurement will start at pre-intervention and end after the intervention. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Bloom Mental HealthLittletonColorado80120-

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Bloom Mental Health· Littleton, CO

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