Transcranial Magnetic Stimulation in Misophonia

Part of paid clinical trials in New York, New York.

Sponsor
Icahn School of Medicine at Mount Sinai
Study ID
NCT06960083
Status
Recruiting
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Conditions

  • Misophonia

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Magnetic Stimulation (TMS) — OTHER
    Transcranial Magnetic Stimulation (TMS) is an FDA-approved non-invasive brain stimulation technology. It is currently used for treating depression. Applications to other disorders such as OCD and anxiety using TMS are currently under investigation. TMS will be administered for 25 minutes.

Study Details

The purpose of the project is to assess the efficacy of parietal transcranial magnetic stimulation in misophonia. N=60 participants will undergo two transcranial magnetic stimulation sessions: one inhibitory and another excitatory. During both sessions, the parietal region will be stimulated. Participants will perform computerized tasks immediately before and after the stimulation, while EEG, heart rate, and skin temperature will be recorded. These recordings will be used to assess if TMS can be used to improve tolerance to misophonia triggers.

Key Dates

Start date
Sep 2, 2025
Status verified
Jun 2026
Primary completion
Oct 1, 2026
Completion
Oct 1, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Active Comparator: Inhibitory-Excitatory (IE) then Excitatory-Inhibitory (EI)
    Participants in this group will receive an inhibitory TMS in the first session and an excitatory TMS in the second session. The two sessions will be separated by 72 hours.
  • Active Comparator: Excitatory-Inhibitory (EI) then Inhibitory-Excitatory (IE)
    Participants in this group will receive an excitatory TMS in the first session and an inhibitory TMS in the second session. The two sessions will be separated by 72 hours.

Primary Outcome Measure

Unpleasantness Rating Scale [ Time Frame: after each session, 72 hours apart (each session is 2 hours) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mount Sinai WestNew YorkNew York10022
Daniela Schiller, PhD
[email protected]
Martijn Figee, MD, PhD
[email protected]
Parul Jain (PRINCIPAL_INVESTIGATOR)

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By research site
Mount Sinai West· New York, NY

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