Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease

Part of paid clinical trials in Huntsville, Alabama.

Sponsor
Regeneron Pharmaceuticals
Study ID
NCT07271186
Phase
PHASE2
Status
Recruiting
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Conditions

  • Diabetic Kidney Disease (DKD)

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • ALN-ANG3 — DRUG
    Administered per the protocol
  • Evinacumab — DRUG
    Administered per the protocol
  • ALN-ANG3 placebo — DRUG
    Administered per the protocol
  • Evinacumab placebo — DRUG
    Administered per the protocol

Study Details

This study is researching experimental drugs called ALN-ANG3 and evinacumab (called "study drugs"). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times

Key Dates

Start date
Jan 9, 2026
Status verified
May 2026
Primary completion
Sep 24, 2027
Completion
Apr 7, 2028

Study Design

Enrollment
270 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: ALN-ANG3 + evinacumab placebo
  • Experimental: ALN-ANG3 + evinacumab
  • Placebo Comparator: ALN-ANG3 placebo + evinacumab placebo

Primary Outcome Measure

Percent change in Urine Albumin to Creatinine Ratio (UACR) [ Time Frame: Baseline to Week 24 ]

Central Contacts

Locations (51)

FacilityCityStateZIPSite coordinators
Apogee Clinical Research, LLCHuntsvilleAlabama35801-
Applied Research Center of ArkansasLittle RockArkansas72205-
AME Clinical ResearchHuntington BeachCalifornia92647-
Amicis Research CenterNorthridgeCalifornia91325-
FOMAT - Vista del Mar Medical GroupOxnardCalifornia93036-
Central Coast NephrologySalinasCalifornia93901-
North America Research InstituteSan DimasCalifornia91773-
Amicis Research CenterSanta ClaritaCalifornia91355-
Valiance Clinical ResearchTarzanaCalifornia91356-
Amicis Research CenterValenciaCalifornia91355-
National Institute of Clinical Research, Inc.VictorvilleCalifornia92392-
D&H Doral Research CenterDoralFlorida33122-
AGA Clinical TrialsHialeahFlorida33012-
Convenient Medical CenterHialeahFlorida33013-
Elixia HollywoodHollywoodFlorida33024-
D&H Pompano Research CenterMargateFlorida33063-
D&H National Research Centers, IncMiamiFlorida33155-
LCC Medical Research InstituteMiamiFlorida33126-
Regenerate Primary Medical Research, LLCMiamiFlorida33155-
Ocean Blue Medical Research Center - Internal MedicineMiami SpringsFlorida33166-
Innovia Research CenterMiramarFlorida33027-
Central Florida Kidney Specialists OakwaterOrlandoFlorida32806-
Bolanos Clinical ResearchPembroke PinesFlorida33026-
Progressive Medical ResearchPort OrangeFlorida32127-
CDC Research InstitutePort Saint LucieFlorida34952-
D&H Tamarac Research CenterTamaracFlorida33321-
Metabolic Research InstituteWest Palm BeachFlorida33401-
Privia Medical Group of Georgia, LLCSavannahGeorgia31406-
Research by Design, LLC - Internal MedicineChicagoIllinois60643-
IMA Clinical ResearchMonroeLouisiana71201-
Elixia Michigan Kidney ConsultantsPontiacMichigan48341-
Elixia MNACity of Saint PetersMissouri63376-
Clinical Research Consultants, LLCKansas CityMissouri64111-
DaVita Clinical ResearchLas VegasNevada89107-
Velocity Clinical ResearchBinghamtonNew York13905-
CHEAR Center LLCThe BronxNew York10455-
Eastern Nephrology Associates - Greenville WestGreenvilleNorth Carolina27834-
Brookview Hills Research Associates, LLCWinston-SalemNorth Carolina27103-
Northeast Clinical Research CenterBethlehemPennsylvania18017-
Suburban Research AssociatesWest ChesterPennsylvania19380-
Southeast Renal Research InstituteChattanoogaTennessee37404-
Arlington Nephrology, PLLC.ArlingtonTexas76015-
M3 Wake Research Dallas - Internal MedicineDallasTexas75224-
Revival Research Institute, LLCDallasTexas75231-
El Paso Kidney Specialists-Davita Clinical ResearchEl PasoTexas79902-
Clinical Trial Network, LLCHoustonTexas77074-
Juno Research, LLCHoustonTexas77040-
Gulf Coast Clinical ResearchKatyTexas77450-
R & H Clinical Research, Inc.KatyTexas77450-
Sunbeam Clinical ResearchMcKinneyTexas75069-
Clinical Advancement CenterSan AntonioTexas78212-

Find similar trials in Huntsville, AL

By research site
Apogee Clinical Research, LLC· Huntsville, ALApplied Research Center of Arkansas· Little Rock, ARAME Clinical Research· Huntington Beach, CAAmicis Research Center· Northridge, CAFOMAT - Vista del Mar Medical Group· Oxnard, CACentral Coast Nephrology· Salinas, CA