Senolytics for Secondary Progressive MS

Part of paid clinical trials in Columbus, Ohio.

Sponsor
Ohio State University
Study ID
NCT07270120
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

  • Multiple Sclerosis (MS) Secondary Progressive

Eligibility Criteria

Sex
ALL
Age
50 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Dasatinib and quercetin — DRUG
    Participants will receive 100 mg of dasatinib and 1250 mg of quercetin orally once a day for 2 days every 2 weeks over 12 consecutive weeks

Study Details

This is a clinical trial to see whether senolytic therapy is safe and feasible for patients with secondary progressive MS and whether treatment improves physical and thinking abilities. The study seeks to enroll adults with secondary progressive MS (SPMS), aged 50-85, who are not currently taking a MS disease-modifying therapy and have noticed their MS symptoms getting worse. People who join the study will take the medicines dasatinib and quercetin by mouth every two weeks for three months. These medicines work together to remove old, damaged cells that may cause inflammation and slow the repair of nerves. Participants will also be followed for one year from enrollment to monitor for treatment effects.

Key Dates

Start date
Jan 15, 2026
Status verified
Dec 2025
Primary completion
Jan 15, 2027
Completion
Jan 15, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment
    Dasatinib and quercetin

Primary Outcome Measure

Participant retention rate [ Time Frame: Baseline until 3 months ]

Locations (1)

FacilityCityStateZIPSite coordinators
Ohio State Martha Morehouse Outpatient CareColumbusOhio43210
Yinan Zhang, MD
[email protected]
614-293-4969
6142934969

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By research site
Ohio State Martha Morehouse Outpatient Care· Columbus, OH

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