Feasibility and Safety of Blood-Flow-Restriction Training in Patients With Hemophilia

Sponsor
University Hospital, Bonn
Study ID
NCT07259356
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Control — DEVICE
    Sham-BFR Exercise (20mmHg) while Leg Press Exercise (4 Sets, All out)
  • BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out) — DEVICE
    BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)

Study Details

In the course of a cross-over study design, 12 patients with hemophilic arthropathy will perform a training load on the knee extensor muscles. The subjects will each perform one intervention with blood flow restriction and one with a Sham-BFR intervention.

Key Dates

Start date
Aug 1, 2024
Status verified
May 2025
Primary completion
Dec 31, 2025
Completion
Mar 1, 2026

Study Design

Enrollment
12 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Active Comparator: Control Condition
    Sham-BFR Leg Press Exercise
  • Experimental: Intervention Condition
    BFR Leg Press Exercise

Primary Outcome Measure

Pain threshold [ Time Frame: Pre- (Baseline, before Exercise) to immediately Post-Intervention (after the exercise training intervention) and 24 hours after intervention ]

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