A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation

Part of paid clinical trials in Fort Wayne, Indiana.

Sponsor
HALEON
Study ID
NCT07255040
Status
Recruiting
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Conditions

  • Dental Plaque
  • Gingivitis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Test Dentifrice — DRUG
    Experimental dentifrice containing 0.454% w/w SnF2.
  • Parodontax Complete Protection — DRUG
    Marketed dentifrice containing 0.454% w/w SnF2.
  • Colgate Cavity Protection — DRUG
    Marketed regular fluoride dentifrice.

Study Details

The aim of this 24-week clinical study is to evaluate the ability of an experimental dentifrice containing 0.454 percent (%) weight by weight (w/w) Stannous fluoride (SnF2); to improve gingival health, plaque reduction and prevention of plaque accumulation compared with a regular fluoride dentifrice (negative control) in participants with mild to moderate gingivitis.

Key Dates

Start date
Nov 19, 2025
Status verified
Dec 2025
Primary completion
Jul 31, 2026
Completion
Jul 31, 2026

Study Design

Enrollment
300 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Test Dentifrice
    Participants will be instructed to brush their teeth thoroughly with Test Dentifrice for at least one (timed) minute twice a day (morning and evening) for 24 weeks.
  • Active Comparator: Reference Dentifrice (Positive Control)
    Participants will be instructed to brush their teeth thoroughly with Reference Dentifrice (Positive Control) for at least one (timed) minute twice a day (morning and evening) for 24 weeks.
  • Active Comparator: Reference Dentifrice (Negative Control)
    Participants will be instructed to brush their teeth thoroughly with Reference Dentifrice (Negative Control) for at least one (timed) minute twice a day (morning and evening) for 24 weeks.

Primary Outcome Measure

Number of Bleeding Sites (Overall) at Week 24 [ Time Frame: Week 24 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Salus Research, Inc.Fort WayneIndiana46825
Jeffery L Milleman
[email protected]

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Salus Research, Inc.· Fort Wayne, IN

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