Variation in Gingival Inflammatory Responses

Part of paid clinical trials in Seattle, Washington.

Sponsor
University of Washington
Study ID
NCT05968742
Status
Recruiting
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Conditions

  • Gingivitis

Eligibility Criteria

Sex
ALL
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Abstinence of oral hygiene on select teeth — BEHAVIORAL
    Study participants abstain from oral hygiene on a select set of four teeth for a period of 21 days

Study Details

The aim of this NIH National Institute of Dental and Craniofacial Research (NIDCR) funded study is to identify molecular mechanisms underlying observed variations in human responses to natural accumulation and maturation of dental plaque.

Key Dates

Start date
Jun 30, 2023
Status verified
Nov 2025
Primary completion
Oct 1, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
80 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Healthy Volunteers
    Study participants abstain from oral hygiene on a select set of four teeth for a period of 21 days. The use of a custom made acrylic intraoral stent (mouthguard) will be used to protect teeth on designated test sides for each study participant during normal oral hygiene (approximately 4 minutes each day: 2 times for 2 minutes) throughout the induction phase (Day 0-21).

Primary Outcome Measure

Identification of clinical responder types [ Time Frame: Day 0 to Day 21 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of WashingtonSeattleWashington98195
Jeffrey S McLean, PhD
[email protected]
(206)-616-1808
Marilyn Rothen
[email protected]
(206) 685-8132
Kristopher A Kerns, PhD (SUB_INVESTIGATOR)

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