Pistachio Intake and Nutrition-Related Outcomes in Individuals on GLP-1 Therapy

Part of paid clinical trials in Clevland, Ohio.

Sponsor
Ian J. Neeland, MD
Study ID
NCT07244445
Status
Recruiting
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Conditions

  • Dietary Change
  • Food Acceptance
  • Obesity & Overweight

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Pistachios — DIETARY_SUPPLEMENT
    Participants will eat 2 ounces, or about 53 grams, of dry-roasted, unsalted pistachios each day along with their regular diet
  • Dual-energy X-ray absorptiometry (DEXA) scans — PROCEDURE
    DEXA scans will be used to measure body fat

Study Details

In this study will look at how eating pistachios every day might affect participants weight, how healthy their diet is, and how they feel when eating. Investigators want to see if adding pistachios to meals for 12 weeks helps participants feel fuller, have more energy, and improve body composition. The study will include adults who have been taking GLP-1 medicines like semaglutide or tirzepatide for at least three months. Investigators also want to see if eating pistachios improves overall diet quality and health markers like tiredness and certain levels in blood.

Key Dates

Start date
Jan 29, 2026
Status verified
Feb 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
108 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Pistachio Group
    Participants in this group will eat 2 ounces, or 53 grams of dry-roasted, unsalted pistachios each day along with their regular diet.
  • Active Comparator: No Pistachio Group
    Participants in this group will continue eating regular diet without pistachios.

Primary Outcome Measure

Change is Satiety as measured by the Hunger and Satiety Visual Analog Scales (VAS) [ Time Frame: Baseline, End of study (12 weeks) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University Hospitals Cleveland Medical CenterClevlandOhio44106
Ian Neeland, MD
[email protected]
216-844-5965
Abigail Raffner, PhD, RD, LD
[email protected]
216-368-0756

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By research site
University Hospitals Cleveland Medical Center· Clevland, OH

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