A Study of Pirtobrutinib, Venetoclax, and Rituximab in People With Waldenström's Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL)

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07231952
Phase
PHASE2
Status
Recruiting
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Conditions

  • Lymphoplasmacytic Lymphoma
  • Waldenstrom Macroglobulinemia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to find out if the combination of pirtobrutinib, venetoclax, and rituximab is an effective treatment for participants with Waldenström's macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL)

Key Dates

Start date
Nov 11, 2025
Status verified
Jun 2026
Primary completion
Apr 11, 2028
Completion
Apr 11, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants with Waldenström's Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL)
    Participants with treatment naive Waldenström's Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL)

Primary Outcome Measure

Number of participants with Very Good Partial Response Rate or Better [ Time Frame: 1 year ]

Central Contacts

Locations (9)

FacilityCityStateZIPSite coordinators
Beth Israel Deaconess Medical Center (Data Collection Only)BostonMassachusetts02215
Gottfried von Keudell, MD
617-667-9920
Dana Farber Cancer Institute (Data Collection and Specimen Analysis)BostonMassachusetts02115
Jorge Castillo, MD
617-632-4218
Memorial Sloan Kettering Basking RidgeBasking RidgeNew Jersey07920
M. Lia Palomba, MD
646-608-3711
Memoral Sloan Kettering MonmouthMiddletownNew Jersey07748
M. Lia Palomba, MD
646-608-3711
Memorial Sloan Kettering BergenMontvaleNew Jersey07645
M Lia Palomba, MD
646-608-3711
Memorial Sloan Kettering Suffolk - CommackCommackNew York11725
M. Lia Palomba, MD
646-608-3711
Memorial Sloan Kettering WestchesterHarrisonNew York10604
M. Lia Palomba, MD
646-608-3711
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
M. Lia Palomba, MD
646-608-3711
Memorial Sloan Kettering NassauUniondaleNew York11553
M. Lia Palomba, MD
646-608-3711

Find similar trials in Boston, MA

By research site
Beth Israel Deaconess Medical Center (Data Collection Only)· Boston, MADana Farber Cancer Institute (Data Collection and Specimen Analysis)· Boston, MAMemorial Sloan Kettering Basking Ridge· Basking Ridge, NJMemoral Sloan Kettering Monmouth· Middletown, NJMemorial Sloan Kettering Bergen· Montvale, NJMemorial Sloan Kettering Suffolk - Commack· Commack, NY

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