Oral 5 Strain Probiotic for GI Toxicity Mitigation During Pelvic Radiation

Part of paid clinical trials in Cincinnati, Ohio.

Sponsor: University of Cincinnati
Study ID: NCT07231588
Phase: EARLY_PHASE1
Status: Recruiting

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Conditions

Radiation Injuries

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Not accepted

Interventions

Pendulum Glucose Control (PGC) — BIOLOGICAL
Pendulum Glucose Control (PGC) WBF-038 - 2 capsules Orally with food. Once daily for 10 weeks

Study Details

This research is to determine if an oral probiotic, Pendulum Glucose Control (PGC), can be safely given to patients during pelvic radiation therapy (RT). The researchers will study if the probiotics lessen gastrointestinal toxicity during pelvic radiation.

Key Dates

Start date: Jan 29, 2026
Status verified: Nov 2025
Primary completion: Jun 29, 2026
Completion: Dec 29, 2026

Study Design

Enrollment: 20 participants (estimated)
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Arms

Experimental: RT + Probiotic
Pendulum Glucose Control (PGC) probiotic + Radiation Therapy Treatment

Primary Outcome Measure

Pendulum Glucose Control (PGC) Probiotic Adherence Rate (PAR)- measured by pill counts [ Time Frame: Week 6 and week 10 ]

Central Contacts

UCCC Clinical Trials Office
513-584-7698
[email protected]
Bailey Nelson, MD

Locations (1)

Facility	City	State	ZIP	Site coordinators
University of Cincinnati Medical Center	Cincinnati	Ohio	45219	UCCC CTO [email protected] 513-584-7698 Bailey Nelson, MD (PRINCIPAL_INVESTIGATOR)

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By research site

University of Cincinnati Medical Center· Cincinnati, OH