Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)

Part of paid clinical trials in Cypress, California.

Sponsor
Novo Nordisk A/S
Study ID
NCT07225816
Phase
PHASE1
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Liraglutide — DRUG
    Participants will receive liraglutide subcutaneously.
  • Oral Semaglutide — DRUG
    Participants will receive semaglutide orally.
  • Semaglutide — DRUG
    Participants will receive semaglutide subcutaneously.

Study Details

The purpose of this study is to investigate how the duration of fasting and temporary stopping of Glucagon-Like-Peptide 1 (GLP-1) medications affect the amount of food left in the stomach in people using liraglutide (injected), semaglutide (taken by mouth) or semaglutide (injected). The length of participants participation in the study will depend on the type of GLP-1 RA treatment participants are already using.

Key Dates

Start date
Nov 7, 2025
Status verified
Jan 2026
Primary completion
Jun 19, 2026
Completion
Jul 17, 2026

Study Design

Enrollment
75 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Liraglutide
    Participants will receive liraglutide subcutaneously.
  • Experimental: Oral semaglutide
    Participants will receive semaglutide orally.
  • Experimental: Semaglutide
    Participants will receive semaglutide subcutaneously.

Primary Outcome Measure

Occurrence of empty stomach (antrum grade 0 or 1) after fasting following a solid, high-fat meal after dosing of subcutaneous (s.c.) liraglutide once daily (Yes/No) [ Time Frame: 6, 8, 10, 12, 18 and 24 hours after start of fasting on Visit 2, Day 1 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Altasciences Clinical LA, Inc.CypressCalifornia90630-

Find similar trials in Cypress, CA

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Altasciences Clinical LA, Inc.· Cypress, CA

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