Adaptive Immune Response in Visceral and Subcutaneous Fat: Role in Human Insulin Resistance

Part of paid clinical trials in Stanford, California.

Sponsor
Stanford University
Study ID
NCT04708535
Status
Enrolling By Invitation

Conditions

  • Inflammation
  • Insulin Resistance
  • Insulin Sensitivity
  • Obesity

Eligibility Criteria

Sex
ALL
Age
30 Years - 65 Years
Healthy Volunteers
Accepted

Study Details

The proposed study is designed to test the hypothesis that in human obesity, the balance of pro- and anti-inflammatory T cells in fat tissue is in fact related to macrophage phenotype and insulin resistance, and how it is related. This study is needed to confirm whether conclusions based on studies of visceral adipose tissue in mice are indeed applicable to humans. We also want to determine the relationship between insulin resistance/hyperinsulinemia and ability to lose weight in obese individuals.

Key Dates

Start date
Aug 1, 2017
Status verified
Apr 2026
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Bariatric Cohort
    For consenting subjects who are undergoing bariatric surgery, a visceral fat sample will be taken during surgery. In addition to the fat sample, insulin resistance will be measured and determined by a modification of the insulin suppression test.

Primary Outcome Measure

T-cell profile in visceral and subcutaneous fat [ Time Frame: baseline (within 2 months prior to bariatric surgery) ]

Locations (1)

FacilityCityStateZIPSite coordinators
Stanford UniversityStanfordCalifornia94305-

Find similar trials in Stanford, CA

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Stanford University· Stanford, CA

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