A Study of LY4167586 in Participants With Obesity or Overweight Who Are Otherwise Healthy

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
Eli Lilly and Company
Study ID
NCT07225556
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • LY4167586 — DRUG
    Administered SC
  • Placebo — DRUG
    Administered SC
  • LY4167586 — DRUG
    Administered IV

Study Details

The purpose of this study is to look at how safe and well-tolerated LY4167586 is in participants with obesity or overweight who are otherwise healthy. Blood tests will be performed to check how much LY4167586 gets into the bloodstream and how long it takes the body to eliminate it following a single administration. Participation in the study will last approximately 7 months.

Key Dates

Start date
Nov 18, 2025
Status verified
Mar 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
84 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: LY4167586 (Cohorts A1 to A6)
    LY4167586 administered subcutaneously (SC)
  • Placebo Comparator: LY4167586 (Cohorts A1 to A6) Placebo
    LY4167586 administered SC
  • Experimental: LY4167586 (Cohort B)
    LY4167586 administered intravenously (IV)

Primary Outcome Measure

Number and Incidence of Serious Adverse Events (SAEs) [ Time Frame: Baseline to study completion (up to 29 weeks) ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    1-317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (1)

FacilityCityStateZIPSite coordinators
Fortrea Clinical Research UnitMadisonWisconsin53704
866-429-3700
Kimberly Cruz (PRINCIPAL_INVESTIGATOR)

Find similar trials in Madison, WI

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Fortrea Clinical Research Unit· Madison, WI

Related Studies