GLP-1 RA on Liver OMICS in MASLD

Part of paid clinical trials in Milwaukee, Wisconsin.

Sponsor
Medical College of Wisconsin
Study ID
NCT06982378
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • GLP-1 receptor agonist — DRUG
    on and not on treatment

Study Details

In patients with type II diabetes mellitus (T2DM) and obesity, an excess plasma-free fatty acid is found with an associated increased lipid accumulation in adipocytes and liver tissue. Lipid droplet accumulation in the hepatocytes is an initial step in the development of metabolic dysfunction associated steatotic liver disease (MASLD. Insulin resistance, which is associated with T2DM, mediates the inflammation of these lipids, resulting in the progression of MASLD to metabolic dysfunction associated steatotic hepatitis (MASH). Hence, in T2DM, obesity, and MASLD, changes in the lipid profile occur, and they are interrelated. In this study, we aim to assess improvement in the lipidomic, its associated metabolic changes and evaluate the co-regulated genes in the liver tissue among patients with MASLD with intervention with GLP-1 RA, which has shown to benefit T2DM and obesity.

Key Dates

Start date
Jul 31, 2026
Status verified
Mar 2026
Primary completion
Dec 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
30 participants (estimated)

Arms

  • Arm: Without GLP-1 RA treatment
    Patients with MASLD and obesity/diabetes - on standard of care treatment but not on any GLP-1 RA
  • Arm: Had GLP-1 RA treatment
    Patients with MASLD and obesity/diabetes - on GLP-1 RA as a standard of care treatment

Primary Outcome Measure

Changes in lipidomics profile on use of GLP-1 RA [ Time Frame: 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Froedtert HospitalMilwaukeeWisconsin53226-

Find similar trials in Milwaukee, WI

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Froedtert Hospital· Milwaukee, WI

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