Tirzepatide to Slow Biological Aging

Part of paid clinical trials in Galveston, Texas.

Sponsor
The University of Texas Medical Branch, Galveston
Study ID
NCT07220473
Phase
PHASE2
Status
Recruiting
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Conditions

  • Aging
  • LONGEVITY 1

Eligibility Criteria

Sex
ALL
Age
55 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Zepbound — DRUG
    Auto injectors with a 2.5 mg dosage are given subcutaneously weekly.

Study Details

This pilot clinical study aims to investigate the potential effects of tirzepatide on biological aging in older adults. In this novel study, 90 adults aged 55-70 years with an indication for tirzepatide weight-loss therapy will be randomized to receive either tirzepatide 2.5 mg subcutaneously (SC) weekly or no drug for 24 weeks, followed by 12 weeks off the drug. Since tirzepatide is already recognized as a highly effective weight-loss agent in this population, the primary focus will not be on measuring weight loss. Instead, the study will document the effects of tirzepatide on markers of aging, physical function, and overall health.

Key Dates

Start date
Feb 27, 2026
Status verified
Mar 2026
Primary completion
Nov 30, 2027
Completion
Jan 31, 2028

Study Design

Enrollment
90 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: Tirzepatide
    Participants will receive Tirzepatide 2.5 mg weekly for 24 weeks, followed by a 12-week off-drug follow-up.
  • No Intervention: Placebo
    Participants will be monitored for a total of 36 weeks without receiving medication.

Primary Outcome Measure

Change in DNA Methylation-Based Biological Age [ Time Frame: Immediately before and after the study visit at Weeks 4, 12, and 24 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Texas Medical BranchGalvestonTexas77555
Lamonne Crutcher
[email protected]
409-772-1619
Thomas Blackwell, MD, FACP (PRINCIPAL_INVESTIGATOR)

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