Metabolic and Functional Consequences of Aging in Health and Disease

Part of paid clinical trials in College Station, Texas.

Sponsor
Texas A&M University
Study ID
NCT05240885
Status
Recruiting
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Conditions

  • Aging

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Stable tracer infusion in a postabsorptive state — OTHER
    Multiple stable-labeled tracers of amino acids, ketoacids, glycerol, short-chain fatty acids

Study Details

Considerable heterogeneity in the aging population has been observed. The exceptional longevity of individuals reaching 100 years old, so-called centenarians may be an example of life-long healthy aging, or added years may be spent in poor health with decreased physical and cognitive functioning. Current knowledge of the aging experience and the trajectories of physical and cognitive decline across various age groups are not well-understood, yet crucial to prevent spending added years in disease. Hence, the study objective is to develop the metabolic profile associated with aging-related disorders measured as the incidence of impaired functional capacity, cognitive function, and/or well-being.

Key Dates

Start date
Mar 4, 2022
Status verified
Sep 2025
Primary completion
Sep 30, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Controls
    Study subjects that are eligible based on inclusion/exclusion criteria Screening visit: body weight and composition by DXA, height, and vital signs will be assessed. Study day(s): may include combinations of stable tracer infusions and with blood draws, cognitive and muscle performance testing

Primary Outcome Measure

Age-related changes in whole-body protein and amino acid metabolism [ Time Frame: 2 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Human Clinical Research BuildingCollege StationTexas77845
Laura Ruebush, PhD
[email protected]

Find similar trials in College Station, TX

By research site
Human Clinical Research Building· College Station, TX

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