Impact of Exogenous Ketones on Breathing in Healthy Volunteers

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT07220122
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Healthy Volunteer

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • 1,3 butanediol — DIETARY_SUPPLEMENT
    40 mg Ketone-IQ beverage
  • Placebo — DIETARY_SUPPLEMENT
    Placebo (taste matched)

Study Details

Exogenous ketones (EK) are compounds that can increase the level of ketones in the body without needing to change what an individual eats. Although EK have been researched mainly in relation to energy and exercise, there haven't been many studies focusing specifically on how EKs affect breathing using well-established scientific methods. The investigators believe that EK may help improve breathing, which could be beneficial for situations like high altitudes, sleep apnea, and exercise. To explore how EK might influence breathing, the investigators are conducting a randomized, placebo-controlled crossover study with healthy volunteers.

Key Dates

Start date
Mar 12, 2026
Status verified
Mar 2026
Primary completion
Jan 10, 2027
Completion
Feb 10, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Ketones first
    Visit 1: ketones, Visit 2: Placebo
  • Experimental: Placebo first
    Visit 1: Placebo, Visit 2: ketones

Primary Outcome Measure

Hypercapnic Ventilatory Response (HCVR) [ Time Frame: During each visit, one measurement at baseline, repeated again 2.5 hours after ingesting Ketone-IQ or Placebo ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Johns Hopkins Bayview Medical CenterBaltimoreMaryland21224
Jonathan C Jun
[email protected]
410-550-0115
MD
[email protected]

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Johns Hopkins Bayview Medical Center· Baltimore, MD

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