Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty

Part of paid clinical trials in Louisville, Kentucky.

Sponsor
University of Louisville
Study ID
NCT07219888
Phase
PHASE4
Status
Enrolling By Invitation

Conditions

  • Osteoarthritis (OA) of the Knee

Eligibility Criteria

Sex
ALL
Age
21 Years - 89 Years
Healthy Volunteers
Not accepted

Interventions

  • oral suzetrigine — DRUG
    patient receives a two-week supply of oral suzetrigine upon discharge
  • oral Oxycodone — DRUG
    Patient will receive a two-week supply of oral Oxycodone upon discharge

Study Details

The purpose this study is determine whether postoperative oral dosage of suzetrigine is effective at controlling postoperative pain and reducing analgesic requirements following primary total knee arthroplasty (TKA) versus a control group of TKA patients receiving postoperative Oxycodone.

Key Dates

Start date
Feb 9, 2026
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Apr 30, 2027

Study Design

Enrollment
140 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Group A: suzetrigine group
    Participant will receive a two-week supply of oral suzetrigine upon discharge. Participant will also receive a 10-pill supply of Oxycodone as a rescue medication.
  • Active Comparator: Group B: Oxycodone group
    Participant will receive a two-week supply of oral Oxycodone upon discharge

Primary Outcome Measure

Daily Opioid Use POD 1-14 [ Time Frame: 2 weeks ]

Locations (1)

FacilityCityStateZIPSite coordinators
UofL HealthLouisvilleKentucky40202-

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By research site
UofL Health· Louisville, KY

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