Intervention for Communication Quality of Life in Primary Progressive Aphasia

Part of paid clinical trials in Austin, Texas.

Sponsor
Maya Henry
Study ID
NCT07219680
Status
Recruiting
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Conditions

  • Logopenic Progressive Aphasia
  • Logopenic Progressive Aphasia (LPA)
  • Logopenic Variant Primary Progressive Aphasia
  • Logopenic Variant of Primary Progressive Aphasia (LPA)
  • Nonfluent Aphasia, Progressive
  • Nonfluent Progressive Aphasia
  • Nonfluent Variant Primary Progressive Aphasia (nfvPPA)
  • Primary Progressive Aphasia(PPA)
  • Progressive Aphasia
  • Semantic Aphasia
  • Semantic Dementia
  • Semantic Variant Primary Progressive Aphasia (svPPA)

Eligibility Criteria

Sex
ALL
Age
40 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Multicomponent Lexical Retrieval Cascade Training — BEHAVIORAL
    In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant targets in multiple communication modalities. Biweekly (45-90 minute) sessions with a clinician target multimodal communication and the use of strategies to support word retrieval. These skills are also trained via daily independent practice. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.
  • Multicomponent Video Implemented Script Training in Aphasia — BEHAVIORAL
    In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Treatment focuses on production of individually-tailored, personally relevant scripts. The participant completes 30 minutes per day of independent practice, during which they speak in unison with a video model. Biweekly (45-90 minute) sessions with a clinician target clear and accurate script production, memorization, and conversational usage, as well as multimodal communication. The participant meets six times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.

Study Details

The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and/or Spanish. The main questions the study aims to answer are: * Is the telerehabilitation program feasible and acceptable for people with PPA and their study partners? * Do participants with PPA and study partners find treatment beneficial? * What patterns of treatment response are seen in participants? * Which outcome measures are most useful for evaluating changes in communication and quality of life? Researchers will compare participants who receive intervention immediately to participants assigned to a waitlist control group (who will receive treatment after a delay) to see whether participation in the treatment program is associated with improvements in communication and quality of life. Participants will: * Take part in speech language therapy sessions delivered by video visit that combine restorative, compensatory, and partner-focused communication strategies. Treatment may take place after a waiting period. * Receive education and communication training together with their partner. * Complete speech, language, and cognitive assessments. * Complete questionnaires about communication abilities, daily functioning, and quality of life.

Key Dates

Start date
Apr 1, 2026
Status verified
Apr 2026
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Other: Waitlist Control
    Individuals in the waitlist-control group will undergo initial assessment followed by a waiting interval of 12 (Multi-VISTA) or 13 (Multi-LRCT) weeks. Following the waiting period, they will again complete baseline assessments prior to the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment).
  • Experimental: Immediate Treatment
    Individuals in the immediate treatment group will undergo initial assessment followed immediately by the treatment phase (co-development of training materials and Multi-VISTA or Multi-LRCT treatment).

Primary Outcome Measure

Change in spoken naming of trained/untrained items [ Time Frame: change from pre-treatment or waitlist to post-treatment or waitlist (12-13 weeks), and follow-up at 3 months post-treatment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of TexasAustinTexas78712
Carly M Millanski, MS
[email protected]
512-471-3420
Camille Wagner Rodriguez, MS
[email protected]
Maya L Henry, PhD (PRINCIPAL_INVESTIGATOR)
Stephanie M Grasso, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Texas· Austin, TX

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