A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Part of paid clinical trials in Gilbert, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT07215559
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to investigate weight reduction with macupatide and eloralintide, alone or in combination, in adult participants with obesity or overweight and with type 2 diabetes. Participation in the study will last about 48 weeks.

Key Dates

Start date
Oct 16, 2025
Status verified
Jun 2026
Primary completion
Mar 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Macupatide (Macupatide + Eloralintide Placebo)
    Participants will be administered macupatide subcutaneously (SC) and eloralintide placebo SC
  • Experimental: Eloralintide (Elorlintide + Macupatide Placebo)
    Participants will be administered eloralintide SC and macupatide placebo SC
  • Experimental: Macupatide + Eloralintide
    Participants will be administered eloralintide SC and macupatide SC
  • Placebo Comparator: Placebo (Macupatide Placebo + Elorlintide Placebo)
    Participants will be administered eloralintide placebo SC and macupatide placebo SC

Primary Outcome Measure

Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 32 ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (26)

FacilityCityStateZIPSite coordinators
Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLCGilbertArizona85296
480-691-2213
Sunildat Maheshwari (PRINCIPAL_INVESTIGATOR)
Synexus Clinical Research US, Inc.PhoenixArizona85020
602-200-3814
Jeffrey Zacher (PRINCIPAL_INVESTIGATOR)
Pima HeartTucsonArizona85741
520329-4139
Paul Bejarano (PRINCIPAL_INVESTIGATOR)
Precision Clinical ResearchSunriseFlorida33351
Jeffrey Schneider (PRINCIPAL_INVESTIGATOR)
SKY Clinical Research Network Group-BrownAtlantaGeorgia30331
888-659-4363
Tamara Brown (PRINCIPAL_INVESTIGATOR)
Teak Research ConsultsLawrencevilleGeorgia30043
Kamar Alabi (PRINCIPAL_INVESTIGATOR)
AGILE Clinical Research Trials, LLCSandy SpringsGeorgia30328
Vasundhara Cheekati (PRINCIPAL_INVESTIGATOR)
Pivotal Research SolutionsStonecrestGeorgia30038
Rabahuddin Syed (PRINCIPAL_INVESTIGATOR)
Rophe Adult and Pediatric Medicine/SKYCRNGUnion CityGeorgia30291
470-317-3604
Dwight Blake (PRINCIPAL_INVESTIGATOR)
Vector Clinical TrialsLas VegasNevada89128
702-750-0000
Cornell Calinescu (PRINCIPAL_INVESTIGATOR)
Premier ResearchTrentonNew Jersey08611
609-392-6666
Herbert Conaway (PRINCIPAL_INVESTIGATOR)
PriMED Clinical ResearchDaytonOhio45429
937-534-4201
William Randall (PRINCIPAL_INVESTIGATOR)
Mercy Family ClinicDallasTexas75208
281-944-3610
Ebere Israel Azubuike, MD (PRINCIPAL_INVESTIGATOR)
Velocity Clinical Research, DallasDallasTexas75230
Dan Lender (PRINCIPAL_INVESTIGATOR)
Biopharma Informatic, LLCHoustonTexas77043
281-944-3610
Agadadash Kuliev (PRINCIPAL_INVESTIGATOR)
PlanIt Research, PLLCHoustonTexas77079
713-973-3415
Prashant Koshy (PRINCIPAL_INVESTIGATOR)
Research Physicians Network, LLCHoustonTexas77089
281-944-3610
Jawad Sarwar, MD (PRINCIPAL_INVESTIGATOR)
Aavon Clinical TrialsRichmondTexas77407
713-282-5600
Namrata Dass (PRINCIPAL_INVESTIGATOR)
Consano Clinical Research, LLCShavano ParkTexas78231
210-545-4900
Michelle Welch (PRINCIPAL_INVESTIGATOR)
Texas Valley Clinical ResearchWeslacoTexas78596
956-431-8090
Eduardo Luna (PRINCIPAL_INVESTIGATOR)
Kalo Clinical ResearchWest Valley CityUtah84120
801-363-7353
Cuper Martinez (PRINCIPAL_INVESTIGATOR)
Eastern Virginia Medical School (EVMS) Medical GroupNorfolkVirginia23510
757-446-5291
Elias Siraj (PRINCIPAL_INVESTIGATOR)
Clinical Research Partners, LLCRichmondVirginia23226
804-477-3045
Robert Call (PRINCIPAL_INVESTIGATOR)
Northwest Clinical Research CenterBellevueWashington98007
Jeena Vaid (PRINCIPAL_INVESTIGATOR)
Rainier Clinical Research CenterRentonWashington98057
425-251-1720
Frances Broyles (PRINCIPAL_INVESTIGATOR)
Universal Research GroupTacomaWashington98405
253-882-1070
Sabrina Benjamin (PRINCIPAL_INVESTIGATOR)

Find similar trials in Gilbert, AZ

By condition
Type 2 diabetesObesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC· Gilbert, AZSynexus Clinical Research US, Inc.· Phoenix, AZPima Heart· Tucson, AZPrecision Clinical Research· Sunrise, FLSKY Clinical Research Network Group-Brown· Atlanta, GATeak Research Consults· Lawrenceville, GA

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