Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease

Part of paid clinical trials in Galveston, Texas.

Sponsor
The University of Texas Medical Branch, Galveston
Study ID
NCT07203287
Phase
PHASE4
Status
Recruiting
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Conditions

  • General Anesthesia
  • Neuromuscular Blockade
  • Post Operative Pulmonary Complications

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Rocuronium — DRUG
    Will be assessing neuromuscular blockade with rocuronium and reversal with sugammadex
  • Cisatracurium — DRUG
    Will be assessing neuromuscular blockade with neostigmine and reversal with neostigmine
  • Sugammadex — DRUG
    Will be assessing neuromuscular blockade with rocuronium and reversal with sugammadex
  • Neostigmine — DRUG
    Will be assessing neuromuscular blockade with neostigmine and reversal with neostigmine

Study Details

The purpose of the study is to determine which combination of neuromuscular blocking agent and reversal agent is safer to use during anesthesia for patients with chronic kidney disease. The main question it aims to answer is "The use of Cisatracurium with neostigmine leads to less post-operative pulmonary complications than Rocuronium with sugammadex."

Key Dates

Start date
Aug 26, 2025
Status verified
Feb 2026
Primary completion
Dec 31, 2026
Completion
Aug 26, 2027

Study Design

Enrollment
490 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Rocuronium and Sugammadex (RS) Group
    The participants will be given rocuronium and sugammadex as part of one of the standard regimens of neuromuscular blockade and reversal.
  • Active Comparator: Cisatracurium and Neostigmine (CN) Group
    The participants will be given cisatracurium and neostigmine as part of one of the standard regimens of neuromuscular blockade and reversal.

Primary Outcome Measure

Post Operative Pulmonary Complications (PPCs) [ Time Frame: 7 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Texas Medical BranchGalvestonTexas77554
Michael Kinsky, MD
[email protected]
409-772-1011

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By research site
University of Texas Medical Branch· Galveston, TX

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