Median Versus Ulnar Nerve Quantitative Electromyography Neuromuscular Blockade Monitoring Comparison

Part of paid clinical trials in Loma Linda, California.

Sponsor
Loma Linda University
Study ID
NCT06553131
Status
Recruiting
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Conditions

  • Neuromuscular Blockade

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Neuromuscular Transmission Monitoring — DEVICE
    A neuromuscular transmission module connected to electrodes applied to the skin and positioned to provide stimulation of a single nerve and monitor the muscular response to nerve stimulation

Study Details

Medications used to relax the muscles are used during surgery. The amount of muscle relaxation can monitored with devices that stimulate a specific nerve and evaluate the muscle response. The response to, and recovery from, medications that relax the muscles are best described for a nerve in the arm called the ulnar nerve. The investigators believe that other nerves in the arm, such as the median nerve, could be used to monitor the amount of muscle relaxation. The purpose of this study is to compare the muscle response at two different nerve sites after giving medications to relax the muscles. This study is going to measure the depth of muscle relaxation during surgery at two different sites. The muscle response to stimulation of the ulnar nerve (located in the arm) will be compared to the muscle response to stimulation of the median nerve (also located in the arm).

Key Dates

Start date
Dec 26, 2024
Status verified
Jan 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
32 participants (estimated)

Arms

  • Arm: Surgical Patients Receiving Non-Depolarizing Neuromuscular Blockade
    Surgical patients having surgery that requires muscle relaxation with non-depolarizing neuromuscular blockers and monitoring of the depth of muscle blockade.The muscle response to nerve stimulation will be compared between the ulnar and median nerve.

Primary Outcome Measure

Neuromuscular transmission nerve monitoring concordance [ Time Frame: Change in time between administration of rocuronium at beginning of surgery and the appearance of one post-tetanic twitch on a monitor, typically 20 minutes after sedation ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Loma Linda University Troesch Medical CenterLoma LindaCalifornia92354
Melissa M McCabe, MD
[email protected]
909-558-4475
Morgan E Blazy, BS
[email protected]
9095584227
Melissa D McCabe, MD (PRINCIPAL_INVESTIGATOR)
Edgardo E Reynoso, BA (SUB_INVESTIGATOR)
Richard L Applegate, MD (SUB_INVESTIGATOR)
Lauren S Pineda, MS (SUB_INVESTIGATOR)
Morgan E Blazy, BS (SUB_INVESTIGATOR)
Michael Benggon, MD (SUB_INVESTIGATOR)
Ryan Lauer, MD (SUB_INVESTIGATOR)

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Loma Linda University Troesch Medical Center· Loma Linda, CA

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