Quantifying Multi-step Avoidance in Anxiety

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Emory University
Study ID
NCT07203027
Status
Not Yet Recruiting

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Conditions

  • Anxiety
  • Anxiety Disorders

Eligibility Criteria

Sex
ALL
Age
22 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Behavioral Tasks with imaging — BEHAVIORAL
    Participants will complete the MDP task only during 3 separate fMRI scanning sessions. After each session, they will complete one week of ambulatory assessment of real-world avoidance behavior (self-reported avoidance behavior) via Emory Qualtrics surveys. In a fourth scanning session, the brain signature of threat imminence constructed in the first set of participants (Aim 1) will be used to predict and modify avoidance behavior (on the task and in a further week of ambulatory assessment of avoidance) in these participants. During their last visit, the behavioral task will be modified to decrease the availability of avoidance choices; subsequent effects on EMA and passive sensing measures will be assessed.

Study Details

This study aims to learn more about avoidance behavior in people with anxiety, using mathematical models of decision-making processes and decoded neural signals of threat imminence. Researchers are investigating anxiety-related behavior and brain function in people with and without anxiety. Investigators are also looking at how behavior and brain function during tasks in the lab relate to avoidance in their daily lives. The investigators will also test whether changing how people avoid things in a behavioral task affects how people avoid things in their everyday life.

Key Dates

Start date
Jan 31, 2027
Status verified
Sep 2025
Primary completion
Jun 30, 2030
Completion
Jun 30, 2030

Study Design

Enrollment
163 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Anxiety and impairing levels of avoidance
    Participants are screened for anxiety and impairing levels of avoidance and will complete questionnaires, a clinical interview, behavioral tasks, scanning, ecological momentary assessment (EMA), and passive sensing. Participants will complete four visits total.

Primary Outcome Measure

Ecological momentary assessment (EMA) [ Time Frame: Baseline, week 1, week 2, week 3, and week 4 ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Emory CollegeAtlantaGeorgia30322-
Facility for Education and Research in Neuroscience (FERN)AtlantaGeorgia30322-

Find similar trials in Atlanta, GA

By research site
Emory College· Atlanta, GAFacility for Education and Research in Neuroscience (FERN)· Atlanta, GA

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