Temporal Interference in Psychiatry (TIP): Neuromodulation Using Temporal Interference

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Emory University
Study ID
NCT07558759
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Electrical stimulation device — DEVICE
    Temporal Interference (TI) stimulation is a non-invasive neuromodulation method which allows focal electrical stimulation of deep brain structures without affecting overlying cortical regions. Areas will be targeted based on tasks being administered under TI and will include areas associated with fear/anxiety expression and inhibition, reward, and general affective processing including cortical areas. Two carrier electric fields offset by a small amount (5-130Hz) will occur during stimulation. Stimulation will be applied between the pairs of electrodes with a current up to a maximum of between 8mA (TI outside the scanner) and 10mA (TI inside the scanner) with envelope frequencies between 1hz-200hz. Multipolar TI will also be used with multiple locations that can be targeted for stimulation by adding more pairs of electrodes.
  • Electrical stimulation device — DEVICE
    Electrodes will be placed in the same locations used for the TI intervention; either a carrier frequency or no electrical current will be delivered to the brain.

Study Details

This study aims to understand the neural, behavioral and clinical effects of temporal interference (TI), a type of neuromodulation method, in healthy populations and in individuals with anxiety and stress-related conditions.

Key Dates

Start date
Apr 30, 2026
Status verified
Apr 2026
Primary completion
Apr 30, 2031
Completion
Apr 30, 2031

Study Design

Enrollment
300 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Temporal Interference (TI) stimulation
    Participants will receive active stimulation for each of 5 intervention sessions, and will receive TI stimulation for a total time of 20-60 minutes. Stimulation will occur during presentation of the visual stimuli on which subjects will conduct behavioral or cognitive tasks.
  • Sham Comparator: Sham TI stimulation
    Participants will receive sham stimulation for each of 5 intervention sessions, where carrier frequency (e.g., 5000Hz) will be applied but no envelope frequency or 0Hz frequency will be applied.

Primary Outcome Measure

Change in Hamilton Anxiety Rating Scale (HAM-A) [ Time Frame: Baseline, 2-5 weeks post-intervention, 6 weeks post-intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Emory UniversityAtlantaGeorgia30322
Rachel Jones
[email protected]
Negar Fani, PhD, ABPP (PRINCIPAL_INVESTIGATOR)

Find similar trials in Atlanta, GA

By condition
PTSD (post-traumatic stress disorder)
By specialty
PsychiatryMental healthBehavioral health
By research site
Emory University· Atlanta, GA

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