Mitigating Neural Hypoexcitability and Weakness During Disuse in Women

Part of paid clinical trials in Manhattan, Kansas.

Sponsor
Kansas State University
Study ID
NCT07166198
Status
Recruiting
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Conditions

  • Muscle Weakness

Eligibility Criteria

Sex
FEMALE
Age
40 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Wrist immobilization — DEVICE
    The wrist immobilization will use a medical device (wrist cast) to immobilize the left, non-dominant wrist for 7 days.
  • Resistance training — BEHAVIORAL
    The cross-education intervention will consist of resistance training on the dominant hand.
  • Resistance training rehabilitation — BEHAVIORAL
    The resistance training rehabilitation will occur for the non-dominant hand following the immobilization phase for all participants.

Study Details

Clinical trial The goal of this clinical trial is to learn how muscle weakness and atrophy develop during short periods of arm immobilization and whether a type of exercise called cross-education can help reduce these effects in women at midlife. The main questions it aims to answer are: What changes happen in the nervous system that lead to weakness when a wrist is immobilized? Can training the opposite arm help maintain muscle strength, muscle size, and nervous system function in the immobilized arm? Researchers will compare women who have their wrist immobilized with or without opposite-arm resistance training. Participants will: Wear a wrist cast on one arm for 7 days Complete strength training with the opposite arm or no training, depending on their group Attend study visits for strength and nervous system testing Have non-invasive tests (like magnetic brain stimulation, muscle recordings, and muscle imaging) to measure how the nervous system and muscle responds

Key Dates

Start date
May 1, 2026
Status verified
Jun 2026
Primary completion
Jan 31, 2027
Completion
Jan 31, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Intervention Group (TRAIN)
    This group will receive the experimental intervention
  • Active Comparator: Control Group (CON)
    This group will not receive the experimental intervention

Primary Outcome Measure

Handgrip Strength [ Time Frame: Baseline, immediately post-immobilization at 1 week, and post-rehabilitation at 3 weeks. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Neuromuscular Physiology LaboratoryManhattanKansas66506
Joshua Carr, PhD
[email protected]
785-532-0700

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Neuromuscular Physiology Laboratory· Manhattan, KS

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