Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

Part of paid clinical trials in Aurora, Colorado.

Sponsor: University of Colorado, Denver
Study ID: NCT06129110
Status: Recruiting

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Conditions

Adiposity
Insulin Resistance
Insulin Sensitivity
Muscle Weakness
Obesity

Eligibility Criteria

Sex: ALL
Age: 18 Years - 70 Years
Healthy Volunteers: Accepted

Interventions

Diet Weight Loss — BEHAVIORAL
Low calorie diet of meal replacement shakes

Study Details

The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. Researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.