Genetics of Neonatal Encephalopathy and Related Disorders

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Boston Children's Hospital
Study ID
NCT07165938
Status
Recruiting
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Conditions

  • Hypoxic Ischaemic Encephalopathy (HIE)
  • Neonatal Encephalopathy

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Study Details

Investigators at Boston Children's Hospital are conducting research in order to better understand the genetic factors which may contribute to neonatal encephalopathy (NE) and related disorders. These findings may help explain the broad spectrum of clinical features and outcomes seen in individuals with a history of NE.

Key Dates

Start date
Feb 4, 2026
Status verified
Mar 2026
Primary completion
Sep 30, 2035
Completion
Sep 30, 2035

Study Design

Enrollment
300 participants (estimated)

Arms

  • Arm: Neonatal Encephalopathy
    Individuals with a history of NE who are less than 6 years old at the time of enrollment and available biological parents. Must be followed clinically at Boston Children's Hospital. Research genomic sequencing with CLIA confirmation of diagnostic findings. Those with an existing genetic diagnosis or who are deceased prior to enrollment are ineligible.

Primary Outcome Measure

Diagnostic yield [ Time Frame: 10 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
Boston Children's HospitalBostonMassachusetts02115
D'Gama Lab
[email protected]
617-355-5254
Alissa D'Gama, MD, PhD (PRINCIPAL_INVESTIGATOR)

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Boston Children's Hospital· Boston, MA

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