Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Emory University
Study ID
NCT07165808
Status
Recruiting
Apply to this trial

Conditions

  • Nicotine Addiction

Eligibility Criteria

Sex
ALL
Age
21 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Nicotine pouch: Low dose — OTHER
    Nicotine pouch: 3-4 mg
  • Nicotine pouch: High dose — OTHER
    Nicotine pouch: 6-8 mg
  • Low pH — OTHER
    Nicotine pouch with low pH level \[\<8.5\]
  • High pH — OTHER
    Nicotine pouch with high pH level \[\>8.5\]

Study Details

The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users. Primary objective is to assess the effect of variation in nicotine concentration in nicotine pouches (NPs) and its interaction effect with pH level on three proximal outcomes of relevance to regulation: (1) sensory experience, (2) product appeal, and (3) abuse liability of NPs.

Key Dates

Start date
Feb 13, 2026
Status verified
Feb 2026
Primary completion
Jan 31, 2028
Completion
Jan 31, 2028

Study Design

Enrollment
84 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Nicotine Pouches group
    Participants will self-administer NPs that differ along two experimental factors: nicotine concentration (low \[e.g., 3-4 mg\] vs. high \[e.g., 6-8 mg\]) and pH level (low \[\<8.5\] vs. high \[≥8.5\]). Each participant will be exposed to all four NP conditions in randomized order, with one condition administered per visit.

Primary Outcome Measure

Abuse liability: Amount of time with Nicotine product [ Time Frame: Visit 1, Visit 2, Visit 3, Visit 4 (all visits within 2-4 weeks) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Rollins School of Public HealthAtlantaGeorgia30322-

Find similar trials in Atlanta, GA

By research site
Rollins School of Public Health· Atlanta, GA

Related Studies