Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO
Part of paid clinical trials in Boston, Massachusetts.
- Sponsor
- Beth Israel Deaconess Medical Center
- Study ID
- NCT07141524
- Status
- Enrolling By Invitation
Conditions
- VA-ECMO
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- Physiology measurements — OTHERMeasurement of lung perfusion (via EIT) and transpulmonary pressure (via esophageal manometry) during decremental PEEP trial
Study Details
The aim of this study is to characterize ventilation/perfusion (V/Q) matching in adult patients receiving peripheral VA ECMO support while on mechanical ventilation, and to evaluate the impact of PEEP titration guided by Electrical Impedance Tomography (EIT) and esophageal pressure measurements on lung mechanics and V/Q optimization.
Key Dates
- Start date
- Jan 27, 2026
- Status verified
- Oct 2025
- Primary completion
- Dec 31, 2026
- Completion
- Feb 28, 2027
Study Design
- Enrollment
- 10 participants (estimated)
- Allocation
- NA
- Intervention model
- SINGLE_GROUP
- Primary purpose
- BASIC_SCIENCE
Arms
- Other: Lung physiology assessmentMeasurement of lung perfusion (via EIT) and transpulmonary pressure (via esophageal manometry) during decremental PEEP trial
Primary Outcome Measure
V/Q match [ Time Frame: 1 hour ]
Locations (2)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02115 | - |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | - |
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