Influence of Melatonin on Cardiovascular and Thermoregulatory Responses to Stress

Part of paid clinical trials in Waco, Texas.

Sponsor
Baylor University
Study ID
NCT07138443
Status
Recruiting
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Conditions

  • Mental Stress
  • Stress

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Melatonin 3 MG Oral Tablet — DIETARY_SUPPLEMENT
    Participants will ingest an acute 3mg oral melatonin tablet
  • Placebo Oral Tablet — DIETARY_SUPPLEMENT
    Participants will ingest a placebo tablet (sugar pill) of the same size, shape, and color of the active melatonin supplement

Study Details

This study aims to evaluate the influence of acute oral melatonin supplementation on cardiovascular and skin temperature responses to mental stress. The hypothesis is that acute melatonin will lead to reduced cardiovascular and skin temperature responsiveness to acute mental stress.

Key Dates

Start date
Aug 31, 2025
Status verified
Aug 2025
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Melatonin (3mg)
    Participants will ingest an acute oral melatonin tablet (3mg) prior to stress reactivity assessment.
  • Placebo Comparator: Placebo
    Participants will ingest a placebo pill of the same color and shape as the melatonin tablet prior to reactivity assessment.

Primary Outcome Measure

Heart Rate Reactivity [ Time Frame: 4 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Baylor University Autonomic Function LaboratoryWacoTexas76706
Jeremy A Bigalke, PhD
[email protected]
254-710-4399
Jeremy A Bigalke, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Baylor University Autonomic Function Laboratory· Waco, TX

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