Asthma Intervention With Residential Ventilation and Air Cleaner (AIRVAC) Study

Part of paid clinical trials in Arlington, Texas.

Sponsor
The University of Texas at Arlington
Study ID
NCT07196436
Status
Recruiting
Apply to this trial

Conditions

  • Asthma Control
  • Pulmonary Function
  • Quality of Life
  • Sleep Quality
  • Stress

Eligibility Criteria

Sex
ALL
Age
5 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Energy Recovery Ventilator — DEVICE
    A mechanical ventilation system that exchanges stale indoor air with fresh outdoor air while transferring heat and moisture between the incoming and outgoing air streams
  • Portable Air Cleaner — DEVICE
    A standalone home device that filters indoor air to remove particulate matter, allergens, and other pollutants
  • Energy Recovery Ventilator (Sham) — DEVICE
    A home-installed ERV unit that operates in recirculation mode only, providing no fresh air exchange or heat/moisture transfer, serving as a placebo for study purposes.
  • Portable Air Cleaner (Sham) — DEVICE
    A portable air cleaner that appears to operate like an active unit but does not contain a HEPA filter and does not clean the air, serving as a placebo for study purposes

Study Details

The primary goal of this study is to investigate the comparative long-term (i.e., 1-year) effectiveness of energy recovery ventilators (ERVs) and portable air cleaners (PACs) in reducing indoor air pollutants and mold levels and improving asthma-related health outcomes in inner-city children and adults with asthma in low-income households in the Dallas-Fort Worth (DFW) metropolitan area, TX. Secondary goals include: (1) examining associations among asthma outcomes, exposure to indoor air pollutants and mold, and housing-related factors, (2) conducting a cost-benefit analysis of ERV and PAC interventions for improving IAQ, mold control, and health outcomes, and (3) evaluating the utility of cost-effective methods and protocols for measuring IAQ and mold for indoor air pollution epidemiology studies and for providing practical information to patients and their physicians. Using a double-blind, placebo-controlled randomized controlled trial, 80 households will be assigned to receive active or placebo versions of ERVs or PACs. Environmental exposures and housing conditions will be monitored alongside comprehensive health assessments, including lung function tests and validated surveys on asthma control, quality of life, stress, and sleep quality.

Key Dates

Start date
Oct 10, 2025
Status verified
Oct 2025
Primary completion
Jan 31, 2028
Completion
Feb 28, 2028

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Active ERV
    A group that will receive an active energy recovery ventilator for 1 year
  • Sham Comparator: Sham ERV
    A group that will receive a sham energy recovery ventilator (recirculation mode only) for 1 year
  • Active Comparator: Active PAC
    A group that will receive an active portable air cleaner for 1 year
  • Sham Comparator: Sham PAC
    A group that will receive a sham portable air cleaner (HEPA filter removed) for 1 year

Primary Outcome Measure

Pulmonary Function (Spirometry) [ Time Frame: Baseline; 6 months; 18 months; 24 months ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of Texas at ArlingtonArlingtonTexas76010
Insung Kang, Ph.D.
[email protected]
312-342-5733
June Young Park, Ph.D. (SUB_INVESTIGATOR)
Yike Shen, Ph.D. (SUB_INVESTIGATOR)
Rebuilding Together North TexasPlanoTexas75025
Tia LaFavor
[email protected]
972-245-6900

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