Remote Fentanyl Test Strip Distribution and Education to Prevent Drug Overdose

Conditions

• Accidental Overdose of Opiate

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Fentanyl test strips — OTHER
  Fentanyl test strips (FTS) are small strips of paper that can detect the presence of fentanyl in illicit drugs.
• Fentanyl test strip education — BEHAVIORAL
  Developed in the R61 phase, the educational intervention will provide participants with knowledge about how to correctly use fentanyl strips.

Study Details

This Type 1 hybrid effectiveness-implementation randomized controlled trial, Remote Fentanyl Test Strip Distribution and Education to Prevent Drug Overdose, aims to address the United States opioid crisis driven by fentanyl and other synthetic opioids by reducing overdose rates. It is supported by and included in the HEAL Initiative. This study would be the first national, fully remote trial to assess the impact of fentanyl test strips on overdose outcomes, using a novel 2x2 design crossing fentanyl test strip distribution and education to determine which approach most significantly reduces overdose rates while minimizing costs. This research will inform scalability around mail-based fentanyl test strip distribution and education programs to address the nation's opioid overdose crisis.

Key Dates

Start date

Jan 31, 2027

Status verified

Apr 2026

Primary completion

Nov 30, 2027

Completion

Nov 30, 2027

Study Design

Enrollment

100 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

PREVENTION

Arms

• Experimental: FDE
  This arm receives both FTS distribution (FTS delivered to their residential address) and education (FDE), as well as a resource list for naloxone and additional FTS if desired.
• Experimental: E
  The Education only (E) arm receives FTS education as well as a resource list for obtaining naloxone and FTS.
• Experimental: FD
  The FTS distribution only (FDE) arm receives FTS delivered to their residential address as well as a resource list for obtaining naloxone and additional FTS, if desired.
• No Intervention: R
  The referral only (R) arm receives a resource list for obtaining naloxone and FTS.

Primary Outcome Measure

Overdose [ Time Frame: Baseline, 1 month, 3 months, 6 months ]

Central Contacts

• Emma S Kay, PhD, MSW
  205-996-5547
  [email protected]

Locations (2)

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