Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences

Part of paid clinical trials in Loma Linda, California.

Sponsor
Loma Linda University
Study ID
NCT07124533
Phase
PHASE3
Status
Not Yet Recruiting

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Conditions

  • Dental Caries
  • Gingival Inflammation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Toothpaste Tablet — DRUG
    Denttabs toothpaste tablets
  • Conventional Toothpaste — DRUG
    Colgate Cavity Protection toothpaste

Study Details

Objectives: To evaluate the effectiveness of toothpaste tablets when compared to conventional dentifrices in removing plaque. Methods: 50 participants are randomized into two groups: Denttabs toothpaste tablets (T) and Colgate's Cavity Protection toothpaste (P). Both groups utilize their assigned dentifrice for 6 weeks. A pre and post-assessment measures the Gingival Index (GI) and Plaque Index (PI) and Decayed, Missing and Filled Teeth (DMFT). A questionnaire on the use of the product is distributed at the end of the study.

Key Dates

Start date
May 31, 2026
Status verified
Jan 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Toothpaste Tablet
    Subjects are instructed to use one toothpaste tablet at each brushing. Brushing is recommended twice daily for two minutes.
  • Active Comparator: Conventional Toothpaste
    Subjects are instructed to use the toothpaste at each brushing. Brushing is recommended twice daily for two minutes.

Primary Outcome Measure

Plaque Index Score at Baseline [ Time Frame: Change between baseline at visit 1 and visit 2, six weeks post baseline ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Loma Linda UniversityLoma LindaCalifornia92350-
Loma Linda University HealthLoma LindaCalifornia92350-

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Loma Linda University· Loma Linda, CALoma Linda University Health· Loma Linda, CA

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