Polymer Induced Liquid Precursor (PILP) in Adults in With Dentin Caries

Part of paid clinical trials in San Francisco, California.

Sponsor
University of California, San Francisco
Study ID
NCT06727110
Status
Recruiting
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Conditions

  • Dental Caries

Eligibility Criteria

Sex
ALL
Age
18 Years - 64 Years
Healthy Volunteers
Not accepted

Interventions

  • PILP Cement — DEVICE
    PILP cement liner.
  • PILP Conditioner — DEVICE
    PILP solution.

Study Details

The goal of this clinical trial is to learn if polymer-induced liquid precursor (PILP) can be used safely to treat dentin caries (cavities) in adults. The main question it aims to answer is: Is PILP (conditioner or liner) safe in adult teeth with dental caries? Researchers will compare PILP to a placebo (a look-alike substance that contains no drug) to see if PILP safely treats cavities in teeth. Participants will: 1) Have PILP or placebo applied to their tooth prior to the placement of a filling in the tooth, 2) Complete two telephone calls within three months of filling placement and 3) Visit the clinic at three months and six months after the placement of the filling.

Key Dates

Start date
Feb 1, 2025
Status verified
Mar 2026
Primary completion
Aug 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: PILP Conditioner and Cement
    PILP conditioner and cement placement prior to tooth restoration.
  • Experimental: PILP Conditioner
    PILP conditioner application prior to tooth restoration.
  • No Intervention: No intervention
    Placement of traditional dental restoration without additional intervention.

Primary Outcome Measure

Pulpal response [ Time Frame: Tooth vitality testing will occur approximatley 3 months and 6 months after placement of the restoration. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California San Francisco, School of DentistrySan FranciscoCalifornia94143
Jean Star, DDS, MPH
[email protected]
415-514-9768
Jessica Snider, MBA
[email protected]
Jean Star, DDS, MPH (PRINCIPAL_INVESTIGATOR)
Ram Vaderhobli, DDS, MS (SUB_INVESTIGATOR)
Stefan Habelitz, PhD (SUB_INVESTIGATOR)

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By research site
University of California San Francisco, School of Dentistry· San Francisco, CA

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