Neurofeedback to Reduce Spontaneous Recovery of Threat Expectancy

Part of paid clinical trials in Princeton, New Jersey.

Sponsor
Trustees of Princeton University
Study ID
NCT07122739
Status
Recruiting
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Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Active Real-time fMRI Neurofeedback — BEHAVIORAL
    Active neurofeedback to target a functional connection associated with increased memory control ability
  • Sham Real-time fMRI neurofeedback — BEHAVIORAL
    Sham neurofeedback

Study Details

This study tests the efficacy of a new behavioral intervention with the goal of reducing spontaneous recovery of threat expectancy in healthy adults. This real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention delivers feedback based on a functional connection between the prefrontal cortex and the hippocampus.

Key Dates

Start date
Jul 17, 2025
Status verified
Feb 2026
Primary completion
Dec 31, 2027
Completion
Jun 30, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Active Neurofeedback
    Active neurofeedback will reinforce negative dlPFC-hippocampal functional connectivity, as this is expected to increase memory control ability.
  • Sham Comparator: Control Neurofeedback
    Participants in the control neurofeedback group will receive the same instructions as the experimental group, but will receive sham neurofeedback.

Primary Outcome Measure

Spontaneous recovery behavior [ Time Frame: Baseline and fourth fMRI session (out of four total fMRI sessions). At most 60 days will elapse between the start of data collection for a participant and their final fMRI session. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Princeton Neuroscience InstitutePrincetonNew Jersey08540
Augustin C. Hennings, Ph.D.
[email protected]

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Princeton Neuroscience Institute· Princeton, NJ

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