Brain Criticality, Oculomotor Control, and Cognitive Effort

Part of paid clinical trials in Piscataway, New Jersey.

Sponsor
Rutgers, The State University of New Jersey
Study ID
NCT06344559
Status
Recruiting
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Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • transcranial magnetic stimulation — DEVICE
    The study intervention involves modulation of cortical excitation to inhibition (E/I) balance in the right frontal eye field (FEF) by means of 2 trains of spaced continuous or intermittent theta burst stimulation (cTBS, iTBS, respectively) using a transcranial magnetic stimulation device. The endpoint of this stimulation will be a decrease (cTBS) or increase (iTBS) in the local E/I ratio that should last at least 60 minutes post-stimulation (Chung et al., 2016). In separate sessions, all participants will receive either active or stimulation to the FEF. The Investigators will contrast the effects of both iTBS and cTBS to sham stimulation and to each other.

Study Details

The project examines electroencephalography, MRI, and behavioral measures indexing flexibility (critical state dynamics) in the brain when healthy young adults do demanding cognitive tasks, and in response to transcranial magnetic stimulation.

Key Dates

Start date
Aug 1, 2024
Status verified
Aug 2024
Primary completion
Jun 1, 2026
Completion
Jun 1, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Continuous theta burst stimulation
    In a cross-over design, all participants will, in one session, receive continuous theta burst stimulation, to the right frontal eye field. Session order will be counter-balanced across participants, and stimulation protocol will be blinded to participants and the Investigator until after data collection is complete.
  • Active Comparator: Intermittent theta burst stimulation
    In a cross-over design, all participants will, in one session, receive intermittent theta burst stimulation, to the right frontal eye field. Session order will be counter-balanced across participants, and stimulation protocol will be blinded to participants and the Investigator until after data collection is complete.
  • Sham Comparator: Sham theta burst stimulation
    In a cross-over design, all participants will, in one session, receive sham theta burst stimulation, to the right frontal eye field. Session order will be counter-balanced across participants, and stimulation protocol will be blinded to participants and the Investigator until after data collection is complete.

Primary Outcome Measure

Critical dynamics - immediate effects of cTBS versus sham stimulation [ Time Frame: Change in correlations recorded during rest, immediately after stimulation, for active versus sham stimulation. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Advanced Human Brain Imaging ResearchPiscatawayNew Jersey08854
Andrew Westbrook, PhD
[email protected]
919-360-5399

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By research site
Center for Advanced Human Brain Imaging Research· Piscataway, NJ

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