Substance Use in Pregnant People - Optimizing Retention in Treatment

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Washington University School of Medicine
Study ID
NCT07104123
Status
Recruiting
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Conditions

  • Contingency Management
  • Postpartum
  • Pregnancy
  • Substance Use Disorder (SUD)

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Social drivers of health screening — OTHER
    Patients will undergo a structured and protocoled screening for social drivers of health and be linked to support services
  • Patients will undergo a program of contingency management — BEHAVIORAL
    Patients will enter into a 12 week program of contingency management

Study Details

Substance use during pregnancy is a leading cause of maternal morbidity and mortality in the United States, with 55-80% of postpartum patients disengaging from substance use disorder (SUD) treatment within one year of delivery. Structural and social determinants of health, including housing instability, transportation barriers, and limited childcare access, further exacerbate disparities in treatment retention. This pilot study, conducted in two specialized prenatal care clinics, evaluates the feasibility and acceptability of two integrated strategies to promote sustained engagement in recovery-oriented services during the perinatal and postpartum periods. Aim 1 implements a standardized social needs screening and referral protocol to connect patients with community-based supports. Aim 2 pilots a contingency management intervention to incentivize recovery-supportive behaviors. Findings will inform the design of a larger multi-site randomized controlled trial to evaluate the impact of these interventions on treatment retention, overdose prevention, and maternal-infant health outcomes.

Key Dates

Start date
Feb 2, 2026
Status verified
Feb 2026
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
40 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Social drivers of health screening
  • Experimental: Contingency Management

Primary Outcome Measure

Social Drivers: Enrollment [ Time Frame: Enrollment Visit ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of MarylandBaltimoreMaryland21201
Makeda Turner
[email protected]
443-328-4738
Courtney Townsel, MD, MSc (PRINCIPAL_INVESTIGATOR)
Washington UniversitySt LouisMissouri63108
Melissa Mills
[email protected]
314-273-2279
Jeannie C Kelly, MD, MS (PRINCIPAL_INVESTIGATOR)
Ana Baumann Walker, PhD (PRINCIPAL_INVESTIGATOR)

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