Intracervical Vasopressin

Conditions

• Retained Products of Conception

Eligibility Criteria

Sex

FEMALE

Age

18 Years - 51 Years

Healthy Volunteers

Not accepted

Interventions

• Intracervical injection of Vasopressin — DRUG
  Intracervical injection of Vasopressin
• Intracervical Injection of saline — DRUG
  Intracervical Injection of saline

Study Details

This randomized study looks at whether using a medicine injected into the cervix of the uterus (intracervical), called vasopressin, helps to achieve better removal of retained products of conception (RPOC). RPOC means that after a pregnancy has ended (through miscarriage, abortion, or delivery), some parts of the pregnancy tissue, usually from the placenta or fetus, have stayed in the uterus. A hysteroscopic removal of RPOC is one type of treatment. This is a surgical procedure where a doctor uses a small camera attached to a thin tube (called a hysteroscope) to look inside the uterus. The main goal of the study is : • To add to the existing research through this study to see if the injection of intracervical vasopressin leads to improved completion rates of hysteroscopic management of RPOC. Participants will: • would be randomized to receive either vasopressin intracervical injection or a placebo injection (non-active saline) during your procedure. Information from the procedure will be collected from the participant's medical record.

Key Dates

Start date

Oct 30, 2025

Status verified

Oct 2025

Primary completion

Aug 1, 2026

Completion

Dec 1, 2026

Study Design

Enrollment

50 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Active Comparator: Treatment
  Vasopressin- 20 mL of a dilute solution (5 units of Vasopressin in 20cc injectable saline)
• Placebo Comparator: Placebo
  20 mL of saline

Primary Outcome Measure

Completion of procedure hysteroscopically [ Time Frame: from start of procedure to end of procedure ]

Central Contacts

• Patti Parker, BSN
  864-455-1510
  [email protected]
• Paul Miller, MD
  894-455-1600
  [email protected]

Locations (1)

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