Image Detection of Impaired Microcirculatory Reperfusion

Conditions

• Ischemic Stroke, Acute
• Large Vessel Occlusion

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• CT Perfusion — DIAGNOSTIC_TEST
  CT perfusion within 90 minutes of complete angiographic reperfusion

Study Details

Stroke affects one patient every 40 seconds in the United States. It is most commonly caused by blood clots that develop in the blood vessels of the brain. These blood clots interrupt the normal flow of blood and oxygen to the nerve cells in the brain. When this occurs, the nerve cells can die, causing permanent damage to that area of the brain. That damage can result in loss of normal function to a patient's vision, strength, sensation, balance, or speech. These changes can remain permanent if blood flow is not restored to the brain. Thankfully, there are treatments available to help get rid of these blood clots. One of these treatments is a procedure to physically remove the blood clot causing stroke. This practice is now routinely done at all major stroke centers. Special imaging for stroke is now available at these major stroke centers. This imaging looks at blood flow in and around the area of brain that is dying. By performing these scans after the procedure, we can see that not all of brain is being saved by the procedure. That is a problem, because we know that saving brain cells can make a big difference in how patients recover from stroke. The purpose of this study is to determine which brain tissue will not get saved by blood clot removal. We will do this by using specialized imaging after the procedure. The study will discover if there is more brain tissue that can be saved after the procedure. Once we can determine this, our next steps will be looking at ways to save this tissue in the studies that follow. For example, we will look to see if medications can be given after the procedure to help save those brain areas. This study lays the groundwork for future studies to help save all the brain tissue we possibly can from dying during the stroke. This is our best chance of getting all patients affected by stroke the opportunity to live their best lives after stroke.

Key Dates

Start date

Sep 30, 2024

Status verified

Jul 2025

Primary completion

Mar 31, 2026

Completion

Mar 31, 2027

Study Design

Enrollment

40 participants (estimated)

Arms

• Arm: Thrombectomy-Treated Subjects with Anterior Circulation Vessel Occlusion
  Patients with anterior circulation LVO or equivalent stroke treated with mechanical thrombectomy.

Primary Outcome Measure

Feasibility of 90-minute CTP and 48-96-hr MRI [ Time Frame: From enrollment to 96 hours ]

Central Contacts

• Yasmin N Aziz, MD
  513-688-5405
  [email protected]
• Christina Mihova

Locations (1)

Find similar trials in Cincinnati, OH

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