Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model

Part of paid clinical trials in Ann Arbor, Michigan.

Sponsor
University of Michigan
Study ID
NCT07094061
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 22 Years
Healthy Volunteers
Accepted

Interventions

  • fMRI — DEVICE
    Participants will have an MRI to scan participants brains and will wear skin conductance electrodes on the hand and fill out questionnaires. Scanning will take approximately 90 minutes. While lying in the scanner, participants will be asked to perform some tasks. The tasks will be presented to participants visually on a screen in the scanner and eye movements will also be tracked during some of these tasks. Participants will respond to stimuli with button presses that are recorded by computer.
  • Questionnaires and surveys — BEHAVIORAL
    Participants will have multiple visits during this study and fill out various surveys at these visits.
  • Behavioral tasks and eye tracking — BEHAVIORAL
    Participants will perform behavioral tasks while having eye-tracking hardware monitor participants eye movements. A video camera will be used to record eye movements during the behavioral tasks.

Study Details

This study seeks to understand individual differences in personality, brain function, and behavior. Study hypothesis: \- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.

Key Dates

Start date
Oct 3, 2025
Status verified
Jun 2026
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
294 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Assessment group

Primary Outcome Measure

Correlation between Pavlovian conditioned approach (PavCA) bias score (out-of-scanner) and composite cannabis use score [ Time Frame: Baseline ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Rachel Upjohn BuildingAnn ArborMichigan48109
Loree Brennan O'Jack, CPA, MHSA
[email protected]
734-232-0227
Lora M Cope, PhD (PRINCIPAL_INVESTIGATOR)
University of MichiganAnn ArborMichigan48109
Paul Holdefer, MPH
[email protected]
734-998-9239
Lora Cope, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Rachel Upjohn Building· Ann Arbor, MIUniversity of Michigan· Ann Arbor, MI

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