Understanding Freezing of Gait Using Brain Signals and Virtual Reality

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT07092995
Status
Enrolling By Invitation

Conditions

  • Freezing of Gait
  • Freezing of Gait Symptoms in Parkinson&Amp;#39;s Disease
  • Parkinson&Amp;#39;s Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • VR Freezing Task — BEHAVIORAL
    Walking overground in immersive virtual reality (VR) environments that provoke freezing episodes
  • Dual Task — BEHAVIORAL
    Walking overground with and without concomitant performance of secondary cognitive or motor task
  • External Cueing — BEHAVIORAL
    Walking overground in immersive virtual reality (VR) environments that provoke freezing episodes with and without addition of visual and auditory cues.

Study Details

Freezing of gait - the inability to start or continue walking - is a particularly disabling problem in Parkinson's disease that has few treatment options. This project records human brain activity from deep brain stimulation (DBS) devices during walking and freezing of gait episodes to understand the pathophysiology of freezing of gait. Findings will lay the foundation for the development of new treatment strategies that address this disabling symptom.

Key Dates

Start date
Nov 1, 2025
Status verified
Nov 2025
Primary completion
Mar 31, 2030
Completion
Mar 31, 2030

Study Design

Enrollment
36 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Experimental
    Neurophysiology and kinematics are measured during gait interventions

Primary Outcome Measure

GPi gait-related spectral power [ Time Frame: Day 1 ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, Los AngelesLos AngelesCalifornia90095-

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University of California, Los Angeles· Los Angeles, CA

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