Percept Transitions in FOG and PD

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
University of Minnesota
Study ID
NCT06848205
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • OFF Parkinson's Medication(s) — OTHER
    Participants will be asked to withhold Parkinson's medications 12 hours prior to their testing visit (if extended-release Parkinson's medications are taken by the participant, they will be asked to withhold these for 24 hours prior to their testing visit).
  • OFF Deep Brain Stimulation — OTHER
    Participants will have their deep brain stimulation turned off at the beginning of their testing visit.

Study Details

The purpose of this research is to examine the possible causes and signs of freezing of gait (FOG) secondary to Parkinson's disease (PD). To achieve this, the study will use the novel (on-label and FDA-approved) local field potential (LFP) measuring capability of the Medtronic Percept™ deep brain stimulation (DBS) system to compare oscillatory activity in people who have Parkinson's disease, with and without freezing of gait (FOG). This will be conducted as three separate experiments, participants may volunteer for one or more experiments: Experiment 1: The first experiment will compare LFPs during gait initiation with and without a cue, in people with (PD+FOG) and without FOG (PD-FOG). Experiment 2: The second experiment will compare LFPs during the successful movement transitions vs. freezing-events during a FOG provocation course in people with FOG. Experiment 3: The third experiment will compare LFPs during rapid alternating movements of the wrist and/or foot, in people with and without FOG

Key Dates

Start date
Feb 26, 2026
Status verified
Mar 2026
Primary completion
Dec 1, 2028
Completion
Jan 1, 2029

Study Design

Enrollment
36 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Parkinson's disease with freezing of gait
    Participants will have a Medtronic Percept DBS device, diagnosis of idiopathic Parkinson's disease (PD), and freezing of gait (FOG).
  • Experimental: Parkinson's disease without freezing of gait
    Participants will have a Medtronic Percept DBS device and diagnosis of idiopathic Parkinson's disease (PD) without having freezing of gait (FOG). Participants in this arm will not be tested in experiment #2.

Primary Outcome Measure

Quantification of the anticipatory postural adjustments magnitudes (cm) [ Time Frame: During the intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Minnesota, Movement Disorders LabMinneapolisMinnesota55455
Madison Aasen, MS
[email protected]
612-505-8325
Sommer Amundsen-Huffmaster, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Minneapolis, MN

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
University of Minnesota, Movement Disorders Lab· Minneapolis, MN

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