A Study of Herbal Supplements in Cancer Survivors With Constipation

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07091084
Status
Recruiting
Apply to this trial

Conditions

  • Cancer
  • Constipation
  • Functional Constipation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • MZRW — DIETARY_SUPPLEMENT
    MZRW herbal formula consists of a 7:1 extract of Huo Ma Ren \[Hemp Seed 33.4%\]; Da Huang (Sheng) \[Rhubarb (Fresh) 22.2%\]; Bai Shao \[Peony (White) 11.1%\]; Zhi Shi \[Aurantium Immaturus 11.1%\]; Hou Po \[Magnolia Bark 11.1%\]; and Xing Ren \[Apricot Kernel 11.1%\] - Taken for 2 weeks intervention and 2 weeks follow-up

Study Details

The purpose of this study is to find out whether MZRW is an effective treatment for constipation in cancer survivors. The researchers will compare MZRW with placebo, a pill that looks like MZRW and is given in the same way, but contains no medication. The researchers will also study the effect MZRW has on the gut microbiome. The gut microbiome is a diverse community of microorganisms living in the digestive system, essential for digestion and immune function.

Key Dates

Start date
Jul 15, 2025
Status verified
May 2026
Primary completion
Jul 15, 2028
Completion
Jul 15, 2028

Study Design

Enrollment
70 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: MZRW
    Participants will receive 2 weeks of MZRW
  • No Intervention: Placebo
    Participants will receive 2 weeks of placebo

Primary Outcome Measure

Difference of spontaneous bowel movements (SBMs) from baseline to week 2 [ Time Frame: 2 weeks ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)Basking RidgeNew Jersey07920
Jun Mao, MD, MSCE
646-608-8552
Memorial Sloan Kettering Monmouth (All Protocol Activities)MiddletownNew Jersey07748
Jun Mao, MD, MSCE
646-608-8552
Memorial Sloan Kettering Bergen (All Protocol Activities)MontvaleNew Jersey07645
Jun Mao, MD, MSCE
646-608-8552
Memorial Sloan Kettering Suffolk- Commack (All Protocol Activities)CommackNew York11725
Jun Mao, MD, MSCE
646-608-8553
Memorial Sloan Kettering Westchester (All Protocol Activities)HarrisonNew York10604
Jun Mao, MD, MSCE
646-608-8552
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065
Jun Mao, MD, MSCE
646-608-8552
Memorial Sloan Kettering Nassau (All Protocol Activities)Rockville CentreNew York11553
Jun Mao, MD, MSCE
646-608-8552

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Memorial Sloan Kettering Basking Ridge (All Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (All Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (All Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk- Commack (All Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (All Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activities)· New York, NY

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