Methamphetamine Cue-reactivity

Part of paid clinical trials in New York, New York.

Sponsor
Icahn School of Medicine at Mount Sinai
Study ID
NCT07086014
Status
Recruiting
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Conditions

  • Methamphetamine Use Disorder

Eligibility Criteria

Sex
MALE
Age
18 Years - 60 Years
Healthy Volunteers
Not accepted

Interventions

  • Cognitive Reappraisal — BEHAVIORAL
    an emotion-regulation strategy while being asked to complete cognitive tasks.

Study Details

In this observational cohort study, the researchers propose to first identify a psychophysiological marker of methamphetamine cue-reactivity and its incubation with abstinence from methamphetamine use (MUD) and examine group-differences between men who have sex with men (MSM) and non-MSM MUD. The primary objective is to identify psychophysiological markers of methamphetamine (MA) cue-reactivity and its abstinence incubation. The secondary objective is to examine group-differences in methamphetamine use disorder (MUD) individuals between homosexual men (MSM) and heterosexual men (non-MSM). The primary endpoint is to assess incubation of cue-reactivity longitudinally with its reduction in cognitive reappraisal, and the secondary endpoint is to examine the impact of cognitive reappraisal on clinical outcomes of methamphetamine use disorder (MUD) in homosexual men (MSM). 2-year long study. Screening and enrollment will be done at different locations of the Addiction Institute of Mount Sinai. The EEG session will be done at Icahn School of Medicine at Mount Sinai. Participation in the research study will be for a single EEG session.

Key Dates

Start date
Aug 19, 2024
Status verified
Jul 2025
Primary completion
Aug 30, 2025
Completion
Aug 30, 2025

Study Design

Enrollment
88 participants (estimated)

Arms

  • Arm: MSM - MUD (Current)
    Participants who are MSM and are currently using methamphetamine (MA abstinence: 2 weeks; range: 1-3 weeks).
  • Arm: MSM - MUD (Abstinent)
    Participants who are MSM and are abstaining from using methamphetamine (MA abstinence: 3 months; range: 2-4 months).
  • Arm: non-MSM - MUD (Current)
    Participants who are not MSM and are currently using methamphetamine (MA abstinence: 2 weeks; range: 1-3 weeks).
  • Arm: non-MSM - SUD (Abstinent)
    Participants who are not MSM and are abstaining from using methamphetamine (MA abstinence: 3 months; range: 2-4 months).

Primary Outcome Measure

Change in EEG-derived late positive potential (LPP) Amplitude [ Time Frame: at approx. 2 weeks and 3 months abstinence ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Icahn School of Medicine at Mount SinaiNew YorkNew York10029
Muhammad A Parvaz, PhD
[email protected]
212-241-3638
Muhammad A Parvaz (PRINCIPAL_INVESTIGATOR)

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