Impact of Seed Cycling on Menstrual Regularity, Dysmenorrhea, and Premenstrual Symptoms

Part of paid clinical trials in Loma Linda, California.

Sponsor
Loma Linda University
Study ID
NCT07052500
Status
Not Yet Recruiting

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Conditions

  • Menstrual Cramps
  • Menstruation
  • Menstruation Disorders

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • Seed Cycling — DIETARY_SUPPLEMENT
    Daily consumption of 1 tablespoon each of flax and pumpkin seeds during the follicular phase and 1 tablespoon each of sunflower and sesame seeds during the luteal phase

Study Details

The purpose of this research is to investigate the impact of seed cycling on menstrual regularity, cramps, and pre-menstrual symptoms in women with an irregular menstrual cycle and/or dysmenorrhea. The research seeks to provide evidence-based insights into the potential benefits of seed cycling as a holistic approach to women's reproductive health. It is expected that your participation will last 3 months. Procedures and Activities. You will be provided with and asked to consume specific seeds daily. The seeds are to be consumed as follows: follicular phase (the period from the first day of menstruation (day 1) to ovulation (day 14) in a typical 28-day cycle): 1 tablespoon flax seeds and 1 tablespoon pumpkin seeds, and luteal phase (the period between ovulation and the start of the next period; typically days 15-28): 1 tablespoon sunflower seeds and 1 tablespoon sesame seeds. Before the intervention and once monthly for a total of 3 cycles, you will be asked to complete an online menstrual health symptom questionnaire (MHSQ) and keep track of your menstrual cycle days on the built-in health tracking app on your electronic device. Risks. Some of the foreseeable risks or discomforts of your participation include the potential for mild gastrointestinal side effects, the potential for allergic reactions, and the possibility of no significant benefit. Benefits. Possible benefits include the potential for improved menstrual cycle regularity, the potential for a reduction in premenstrual syndrome (PMS) symptoms, and the potential for nutritional benefits. Societal benefits include additional knowledge on seed cycling to help manage menstrual regularity and PMS symptoms.

Key Dates

Start date
May 31, 2026
Status verified
Jan 2026
Primary completion
Sep 30, 2026
Completion
Nov 30, 2026

Study Design

Enrollment
50 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Seed Cycling single arm intervention
    Subjects will receive sunflower seeds, pumpkin seeds, flaxseed and sesame seeds during the intervention

Primary Outcome Measure

Change in menstrual cycle from irregular to regular [ Time Frame: 3 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
School of Allied Health ProfessionsLoma LindaCalifornia92354
Lesley Ann Foster- Nicholas, DrPH, MPH, RDN
[email protected]
9095581000
Edward Bitok, DrPH, MS, MPH
[email protected]
9095581000
Sumrite Aeri, Bs (SUB_INVESTIGATOR)
Victoria LLerena, Bs (SUB_INVESTIGATOR)

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School of Allied Health Professions· Loma Linda, CA

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