The Effect of the Menstrual Cycle on Immune Cell Activity and Recovery After Resistance Exercise

Part of paid clinical trials in Orlando, Florida.

Sponsor
University of Central Florida
Study ID
NCT06985420
Status
Recruiting
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Conditions

  • Healthy Women
  • Menstruation
  • Resistance Exercise

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 40 Years
Healthy Volunteers
Not accepted

Interventions

  • Resistance exercise — OTHER
    Resistance Exercise Protocols: Participants will perform exercises, including belt squats, hex bar deadlifts, and plyometric drop jumps. The load and intensity will be standardized based on each participant's 1-repetition maximum (1RM) to ensure uniformity across trials.
  • Menstrual Cycle Phases — OTHER
    Menstrual Cycle Phases: The key exposure variable is the phase of the menstrual cycle, with participants being assessed during the early follicular, late follicular, and mid-luteal phases.

Study Details

The goal of this observational study is to learn how the menstrual cycle affects immune cell activation, recruitment, and recovery responses after resistance exercise in healthy, resistance-trained women aged 18-40. The main questions it aims to answer are: Does the menstrual cycle influence neutrophil recruitment and adhesion after resistance exercise? Does the menstrual cycle affect markers of muscle damage and functional recovery? Researchers will compare three menstrual phases (early follicular, late follicular, and mid-luteal) to see if immune responses and recovery outcomes differ across these phases. Participants will: Complete resistance exercise protocols across three different menstrual cycle phases. Provide blood samples to assess immune cell activation and muscle damage markers. Track sleep, mood, and recovery with questionnaires and wear an accelerometer.

Key Dates

Start date
Aug 16, 2024
Status verified
May 2025
Primary completion
May 31, 2025
Completion
May 31, 2025

Study Design

Enrollment
40 participants (estimated)

Primary Outcome Measure

Neutrophil Recruitment and Adhesion Dynamics [ Time Frame: From enrollment, through study completion, an average of 4 months. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Central FloridaOrlandoFlorida32816
Jessica M Moon
[email protected]
407-823-0623
Jessica M Moon (PRINCIPAL_INVESTIGATOR)

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By research site
University of Central Florida· Orlando, FL

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