The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments

Part of paid clinical trials in Dallas, Texas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT07050264
Status
Recruiting
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Conditions

  • Body Temperature Regulation
  • Burn Injury
  • Cardiovascular Physiology

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Simulated burn injury via application of absorbent and impermeable material over 60% of the body — OTHER
    Simulated burn injury via application of absorbent and impermeable material over 60% of the body

Study Details

Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise/environmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.

Key Dates

Start date
Mar 1, 2026
Status verified
May 2026
Primary completion
Aug 1, 2028
Completion
Aug 1, 2028

Study Design

Enrollment
28 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Hot and Humid with simulated burns
    Individuals will be exposed to hot and humid conditions with a simulated burn injury.
  • No Intervention: Hot and Humid without simulated burns
    Individuals will be exposed to hot and humid conditions without a simulated burn injury.
  • Experimental: Hot and Dry with simulated burns
    Individuals will be exposed to hot and dry conditions with a simulated burn injury.
  • No Intervention: Hot and Dry without simulated burns
    Individuals will be exposed to hot and dry conditions without a simulated burn injury.

Primary Outcome Measure

Core Temperature [ Time Frame: From baseline to end of 60 minutes of recovery ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital DallasDallasTexas75231
Erin M Harper, B.S.
[email protected]
214-345-4737
Craig G Crandall, PhD
[email protected]
Elizabeth A Gideon, PhD (SUB_INVESTIGATOR)

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By research site
Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas· Dallas, TX

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