Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.

Part of paid clinical trials in Muncie, Indiana.

Sponsor
Ball State University
Study ID
NCT07045051
Status
Recruiting
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Conditions

  • Healthy Participants

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Low-Glycemic Breakfast Containing Oats and Mango — OTHER
    Low-glycemic breakfast of 80 grams of oats prepared with 473mL water and sweetened with 146 grams of mango.
  • High-Glycemic Breakfast Containing Cereal and Mango — OTHER
    High-glycemic breakfast of 84 grams of corn flakes prepared with 355mL of 2% milk and sweetened with 262 grams of mango.
  • Low-Glycemic Breakfast Containing Oats and Table Sugar — OTHER
    Low-glycemic breakfast of 80 grams of oats prepared with 473mL of water and sweetened with 20 grams of table sugar.
  • High-Glycemic Breakfast Containing Cereal and Table Sugar — OTHER
    High-glycemic breakfast of 84 grams of corn flakes prepared with 355mL of 2% milk and sweetened with 36 grams of table sugar.

Study Details

Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose.

Key Dates

Start date
Mar 26, 2025
Status verified
Jun 2025
Primary completion
Dec 1, 2026
Completion
Dec 1, 2026

Study Design

Enrollment
24 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Cereal Consumption with Mango
    During the Cereal and Mango arm, participants will consume a bowl of corn flakes with 2% milk sweetened with fresh mango.
  • Experimental: Cereal Consumption with Table Sugar
    During the Cereal and Table Sugar arm, participants will consume a bowl of corn flakes with 2% milk sweetened with table sugar.
  • Experimental: Oat Consumption with Mango
    During the Oats and Mango Arm, participants will consume a bowl of oats prepared with water and sweetened with fresh mango.
  • Experimental: Oat Consumption with Table Sugar
    During the Oat and Table Sugar arm, participants will consume a bowl of oats prepared with water and sweetened with table sugar.

Primary Outcome Measure

Glucose [ Time Frame: Through study completion, up to 1.5 years. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Health Professions Building, Ball State UniversityMuncieIndiana47306
Bryant Keirns, PhD
[email protected]
765-285-8356

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By research site
Health Professions Building, Ball State University· Muncie, IN

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